Synthesis of α-Aminophosphonates via Phosphonylation of an Aryne–Imine Adduct
  • 2020-10-16

Taehyun Lim, 김병문,
Journal of Organic Chemistry   85(20),  pp.13246-13255  (2020)

Multicomponent phosphonylation is accomplished upon the reaction of an imine with an aryne generated in situ in the presence of a dialkyl phosphite. This transition-metal-free protocol shows a broad substrate scope, providing a variety of α-aminophosphonates in moderate to good yields. A plausible mechanism for the reaction is proposed based on a deuterium exchange experiment.