940
석차옥Professor
  • E-MAILchaok@snu.ac.kr
  • ADDRESS502-203

  • OFFICE+82-2-880-9197FAX+82-2-889-1568LAB+82-2-880-4355

Current Research Interests
Our ultimate goal is to understand detailed mechanisms underlying biological phenomena using computational and theoretical tools, and to contribute to curing diseases using the knowledge obtained from such studies. We are currently developing mathematical and computational techniques to model and to simulate biomolecules more efficiently and accurately. An example is an analytical loop closure method that can be used to model flexibilities in proteins loops and cyclic peptides. We will apply these methods to prediction of protein structures and biomolecular interactions, and also extend such experiences to design of new drugs and proteins.


Education
B.S. Chemistry, Seoul National University, Korea, 1993

M.S. Chemistry, University of Chicago, USA, 1995

Ph.D. Chemistry, University of Chicago, USA, 1998


Research Experiences
Research Associate, University of Chicago, 1999

Research Associate, Massachusetts Institute of Technology, 2000

Research Associate, University of California, San Francisco, 2000-2004


Representative Publications
"Strength of Ca-H...O=C Hydrogen Bonds in Transmembrane Proteins", H. Park, J. Yoon, and C. Seok*, J. Phys. Chem. B, 112, 1041-1048 (2008).

"A statistical rescoring scheme for protein-ligand docking: Consideration of entropic effect", J. Lee and C. Seok*, Proteins: Structure, Function, and Bioinformatics, 70, 1074-1083 (2008).

"Use of the Weighted Histogram Analysis Method for the Analysis of Simulated and Parallel Tempering Simulations", J. D. Chodera, W. C. Swope, J. W. Pitera, C. Seok, and K. A. Dill, Journal of Chemical Theory and Computation, 3, 26 (2007).

"Using Quaternions to Calculate RMSD", E. A. Coutsias, C. Seok*, and K. A. Dill, J. Comput. Chem. 25, 1849 (2004).

"A Kinematic View of Loop Closure", E. A. Coutsias, C. Seok*, M. P. Jacobson, and K. A. Dill, J. Comput. Chem. 25, 510 (2004).

MORE Laboratory

list