Chemistry

서필준Associate Professor

• E-MAILpjseo1@snu.ac.kr

• ADDRESS503-310, 329

• OFFICE+82-2-880-7763FAX+82--LAB+82-2-880-4366

Current Research Interests
In the eukaryotic nucleus, DNA wraps around histone octamers to form nucleosomes. The nucleic acids and histones frequently undergo chemical modifications, and these modifications influence overall chromatin structure to regulate DNA-dependent processes including transcription, replication, DNA repair and recombination in living organisms. Our primary research goal is to understand fundamental mechanisms of chromatin-based gene regulation. We study how distinct chromatin modifications coordinate with each other and how various chromatin factors are recruited to chromatin to translate epigenetic information into gene expression. Furthermore, information and function of a genome are not only decorated with epigenetic marks in the linear DNA sequence but also in their non-random spatial organization in the nucleus. We also aim to extend our understanding of dynamic coupling between 3D chromatin organization and epigenetic regulation.

Education
B.S. Department of Plant Science, Seoul National University, Korea, 2005
Ph.D. Department of Chemistry, Seoul National University, Korea, 2010

Research Experiences
Postdoctoral Researcher, Seoul National University, Korea, 2010-2011
Postdoctoral Researcher, Max Planck Institute for Chemical Ecology, Germany, 2011-2012
Assistant Professor, Chonbuk National University, Korea, 2012-2016
Associate Professor, Sungkyunkwan University, Korea, 2016-2018
Associate Professor, Seoul National University, Korea, 2018-present

Representative Publications
Lee K, Seo PJ*. (2018) Dynamic epigenetic changes during plant regeneration. Trend Plant Sci. 23:235-247.
Lee K, Park OS, Seo PJ*. (2017) Arabidopsis ATXR2 deposits H3K36me3 at the promoters of LBD genes to facilitate cellular dedifferentiation. Science Signaling 10: eaan0316.
Lee HG, Seo PJ*. (2016) The Arabidopsis MIEL1 E3 ligase negatively regulates ABA signaling by promoting protein turnover of MYB96. Nat. Commun. 7: 12525.
Seo PJ, Mas P. (2014) Multiple layers of posttranslational regulation refine circadian clock activity in Arabidopsis. Plant Cell 26: 79-87.
Seo PJ, Kim MJ, Ryu JY, Jeong EY, Park CM. (2011) Two splice variants of the IDD14 transcription factor competitively form nonfunctional heterodimers which may regulate starch metabolism. Nat. Commun. 2: 303.

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