4051
이철범 Professor
  • E-MAILchulbom@snu.ac.kr
  • ADDRESS503-602

  • OFFICE+82-2-880-6650FAX+82-2-889-1568LAB+82-2-880-4346

Current Research Interests
Our program is broadly based on modern organic chemistry (organic synthesis, organometallic chemistry, asymmetric catalysis, natural product total synthesis, bioorganic chemistry). We are developing synthetic tools (reactions and reagents) and networks of reactions (synthetic strategies) for efficient and selective chemical synthesis. In particular, we focus on the development of chemical transformations that can resolve longstanding synthetic problems and offer new mechanistic vistas for future development in organic synthesis. Our investigations are also concerned with the synthesis of natural products with complex molecular architecture and significant biological activities. Our goal is to establish synthetic roadmaps to the target molecules, to evolve new synthesis logics, and to uncover the molecular bases for the peculiar properties of these compounds.

1. New Reaction Development
The research in this area involves discovering, understanding, and exploiting new catalyst systems that effect bond formation with control of chemo-, regio- and stereoselectivities. Our approach is to identify novel reactivities and mechanistic motifs of transition metal-mediated processes to develop conceptually new reactions of broad synthetic utility. Specific topics include the development of stereoselective carbon-heteroatom bond-forming reactions for the asymmetric synthesis of chiral ethers and amines, and new cyclization reactions using alkynes via transition metal vinylidene mediated catalysis.

2. Total Synthesis of Natural Products
Target molecules in our lab include a variety of natural products possessing interesting structural, biological, and physical properties. In each project, we probe the feasibility of unprecedented reactions or untested networks of reactions in complex structural and functional settings. By undertaking these chemical synthesis investigations, we aim to develop innovative new chemistry that will be of great utility in broader contexts. Thus, our endeavor will not only advance synthetic science but also foster opportunities for further biomedical explorations utilizing these molecular agents.


Education
BS/MS. Chemistry, Seoul National University 1990

Ph.D. Chemistry, Stanford University, California, USA, 1998


Research Experiences
Associate Professor, Department of Chemistry, Seoul National University, Korea , 2008-Present

Assistant Professor, Department of Chemistry, Princeton University, New Jersey, USA, 2001-2008

US Army Cancer Research Postdoctoral Fellow, Memorial Sloan-Kettering Cancer Center, New York, USA, 1999-2001

Teaching and Research Assistant, Institute for Basic Research, 1991-1992


Representative Publications
“Ruthenium-Catalyzed Carboxylative Cyclization of 1,6-Diynes,” Hahn Kim, Stephen D. Goble and Chulbom Lee J. Am. Chem. Soc. 2007, 129, 1030-1031.

“Tandem Cyclization of Alkynes via Rhodium Alkynyl and Alkenylidene Catalysis,” Jung Min Joo, Yu Yuan and Chulbom Lee J. Am. Chem. Soc. 2006, 128, 14818-14819.

“Rhodium-Catalyzed Cyclization of N-Propargyl Enamine Derivatives,” Hahn Kim and Chulbom Lee J. Am. Chem. Soc. 2006, 128, 6336-6337.

“Ruthenium-Catalyzed Hydrative Cyclization of 1,5-Enynes,” Yiyun Chen, Douglas M. Ho and Chulbom Lee J. Am. Chem. Soc. 2005, 127, 12184-12185.

“Total Synthesis of Kendomycin: A Macro-C-Glycosidation Approach,” Yu Yuan, Hongbin Men and Chulbom Lee J. Am. Chem. Soc. 2004, 126, 14720-14721.

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