15698
이홍근Assistant Professor
  • E-MAILhgleee@snu.ac.kr
  • ADDRESS503-620,606

  • OFFICE+82-2-880-6651FAX+82--LAB+82-2-880-4364

Current Research Interests
Our mission is to address unmet synthetic needs to solve various problems of biomedical research. To this end, novel strategies to access natural and unnatural small molecules as well as biopolymers are being investigated. More specifically, we are developing target-oriented syntheses that can rapidly increase the molecular complexity of the desired therapeutics. At the same time, transition metal-based synthetic methods that should allow for the preparation of analogues of biologically important biopolymers are being explored. Eventually, the accumulated knowledge should serve to solve problems associated with important therapeutic issues, such as opioid addiction and antibiotic resistance.
 
Education
B.S. Chemistry, Seoul National University, Republic of Korea, 2002
M.S. Chemistry, Seoul National University, Republic of Korea, 2006
Ph.D. Chemistry, Harvard University, USA, 2012
 
Research Experience 
Assistant Professor, Seoul National University, Republic of Korea, 2017-Present 
Research Investigator, Bristol-Myers Squibb, USA, 2016-2017
Postdoctoral Associate, MIT, USA, 2012-2016
 
Representative Publications
“Palladium-mediated Arylation of Lysine in Unprotected Peptides.”
Lee, H. G.; Lautrette, G.; Pentelute. B. L.; Buchwald, S. L. Angew. Chem. Int. Ed.2017, 56, 3177.
 
“Virtually Instantaneous, Room-temperature [11C]-Cyanation Using Biaryl Phosphine Pd(0) Complexes.”
Lee, H. G.; Milner, P. J.; Placzek, M. S.; Buchwald, S. L.; Hooker, J. M. J. Am. Chem. Soc. 2015, 137, 648.
 
“Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides.”
Lee, H. G.; Milner, P. J.; Buchwald, S. L. J. Am. Chem. Soc. 2014, 136, 3792.
 
“Enantioselective Synthesis of the Full Carbon Skeleton of the Lomaiviticin Aglycone Reveals Remarkable Remote Substituent Effects in the Dimerization Event.”
Lee, H. G.; Ahn, J.; Lee, A. S.; Shair, M. D. Chem. Eur. J.2010, 16, 13058.

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