15511
이정호Assistant Professor
  • E-MAILjungho.lee@snu.ac.kr
  • ADDRESS503-324, 500-B217,218

  • OFFICE+82-2-880-4363FAX+82--LAB+82-2-880-4372

Current Research Interests
We use nuclear magnetic resonance (NMR) spectroscopy to gain insight into protein aggregation processes and biomolecular interactions. Intrinsically disordered proteins (IDP), whose aggregation in human brains are often responsible for neurological disorders, are used as model systems to investigate protein aggregation and disaggregation processes. Key factors that determine the interface and affinity of biomolecular interactions are sought for, again assisted by NMR spectroscopy together with other physical chemistry and biophysical techniques. These aggregation and interaction studies will eventually be performed inside a cellular milieu, as an effort to understand health and cure disease starting from the physical chemistry level.

A fascinating aspect of NMR is that its method developments continuously push the boundary of its applicability. In particular, overcoming NMR’s intrinsically low sensitivity holds great promise, and we are developing various methods that can open new NMR applications in different areas of science.

Education
B.S. Mechanical and Aerospace Engineering, Physics (double major),
Seoul National University, Korea, 1997-2002

M.S. Interdisciplinary Program in Genetic Engineering,
Seoul National University, Korea, 2005-2007

Ph.D. Biophysics, University of Wisconsin-Madison, USA, 2008-2013

Research Experiences
Researcher, Lab of Computational Biology and Biomolecular Engineering,
Seoul National University, 2008

Postdoctoral Fellow, Laboratory of Chemical Physics, NIDDK, NIH, USA, 2014-2016

Representative Publications
Lee J.H., Ying J. and Bax A. "Quantitative evaluation of positive phi angle propensity in flexible regions of proteins from three-bond J couplings", Phys. Chem. Chem. Phys. 18, 5759 (2016).

Lee J.H., Zhang D., Hughes C., Okuno Y., Sekhar A. and Cavagnero S. "Heterogeneous binding of the SH3 client protein to the DnaK molecular chaperone", Proc. Natl. Acad. Sci. U.S.A. 112, E4206 (2015).

Lee J.H., Li F., Grishaev A., and Bax A. "Quantitative residue-specific protein backbone torsion angle dynamics from concerted measurement of 3J couplings", J. Am. Chem. Soc. 137, 1432 (2015).

Lee J.H., Okuno Y. and Cavagnero S. "Sensitivity enhancement in solution NMR: Emerging ideas and new frontiers", J. Magn. Reson. 241, 18 (2014).

Lee, J.H., Sekhar, A. and Cavagnero, S. "1H-detected 13C Photo-CIDNP as a sensitivity enhancement tool in solution NMR", J. Am. Chem. Soc. 133, 8062 (2011).

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