Chemistry

이형호Associate Professor

• E-MAILhyungholee@snu.ac.kr

• ADDRESS503-108

• OFFICE+82-2-880-4129FAX+82--LAB+82-2-880-4130

Current Research Interests
The protein-protein (or membrane lipid) interplays are central to almost every aspect of cell biology. We are interested in fundamental questions of how the interactions between proteins and proteins (or membranes) determine cell and organelle shape, how protein-protein or protein-lipid interactions turn on and off the signals that control essential cell processes including cytokinesis, which is the final stage of cell division. We are also highly interested in determining atomic structures of membrane proteins.

It is easy to agree that "Seeing is believing". The roots of our research are in the power of x-ray crystallography to reveal the structures of biomolecules at atomic level, leading to insights in the physical basis of protein-protein interactions. The core approach is complemented by studies in solution or on membranes by hydrodynamic, small angle x-ray scattering, fluorescence imaging, and electron microscopy. The structural, biochemical, and biophysical experiments lead to new hypotheses about biological function and mechanism. We also try to demonstrate our new hypotheses in cells using various cell biological tools.

Crystal structures of drug target proteins can also be used to discover new lead compounds by structure-based drug discovery (SBDD) method. We are interested in various drug target proteins to treat various diseases including cancer.


Education
B.S. Food Science and Biotechnology, Seoul National University, Korea, 2000

M.S. Chemistry, Seoul National University, Korea, 2002

Ph.D. Chemistry, Seoul National University, Korea, 2007


Research Experiences
Assistant Professor, Department of Bio & Nano Chemistry, Kookmin University, 2010-2014

Postdoctoral Fellow, NIDDK, National Institutes of Health, USA, 2007-2010

Postdoctoral Researcher, The Research Institute of Basic Sciences, Seoul National University, 2007-2007


Representative Publications

"Non-canonical DNA binding mode of repressor and its disassembly by antirepressor," Kim M, Kim HJ, Son SH, Yoon H-J, Lim Y, Lee JW, Seok Y-J, Jin KS, Yu YG, Kim SK, Ryu S* and Lee HH* Proc. Natl. Acad. Sci. USA 113(18), E2480-E2488 (*co-corresponding authors) (2016)

"Structural and biochemical insights into the role of TEX14 in forming the stable intercellular bridges of germ cells," Kim HJ, Yoon J, Matsuura A, Na JH, Lee WK, Kim H, Choi JW, Park JE, Park SJ, Kim KT, Chang R, Lee BI, Yu YG, Shin YK, Jeong C, Rhee K and Lee HH. Proc. Natl. Acad. Sci. USA. 112(40), 12372-12377 (2015)

"Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140," Lee WK, Son SH, Jin BS, Na JH, Kim SY, Eunice EK Kim, Yu YG*, Lee HH* Proc. Natl. Acad. Sci. USA. 110(48), 19360-19365 (*co-corresponding authors) (2013)

"Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55," Lee HH, Elia N, Ghirlando R, Lippincott-Schwartz J, Hurley JH. Science 322(5901), 576-580 (2008)

"Structural and functional insights into Dom34, a key component of No-Go mRNA decay," Lee HH, Kim YS, Kim KH, Heo I, Kim SK, Kim O, Kim HK, Yoon JY, Kim HS, Kim DJ, Lee SJ, Yoon HJ, Kim SJ, Lee BG, Song HG, Kim VN, Park CM, Suh SW. Molecular Cell 27(6), 938-950 (2007)

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