14632
데이비드 첸Professor

Current Research Interests
Total synthesis, a research field that renders the preparation of larger molecular constructs from their structurally simplified progenitor(s) through a series of carefully coordinated synthetic operations, has admirably served the scientific community through its contributions in both fundamental chemical research and in a wide-spectrum of physical and biological applications. Our research activity rests its foundation on complexity-inspired total synthesis, with strong emphasis on the design and orchestration of innovative synthetic strategies by employing modern synthetic technologies based on transition-metal and organo-catalysis. Convergent and yet flexible approach are pursued in order to maximize overall synthetic efficiency, and enable the preparation of rationally designed analogues for chemical-biology investigations. Novel reactivities bestowed by complex molecular architectures are explored in a methodological manner and further applied in the context of target-oriented synthesis.

Education
Ph.D. Chemistry, University of Cambridge, 2001

B.Sc. (1st class Hon) Chemistry, University of Auckland, 1998

Research Experiences
Principal Investigator, Agency for Science, Technology and Research, Singapore, 2005-2011

Senior Research Chemist, Merck Research Laboratory, Rahway, USA, 2003-2005

Research Associate, Scripps Research Institute, La Jolla, USA, 2002-2003

Research Assistant, Auckland Cancer Society Research Center, New Zealand, 1998


Representative Publications
" Formal Syntheses of (-)- and (+)-Phalarine."
Ding H., and Chen D. Y. -K.* Angew. Chem. Int. Ed. 2011, 50, 676-679.

" Formal Asymmetric Synthesis of Echinopines A and B."
Peixoto P. A., Severin. R., Tseng C.-C, and Chen D. Y. -K.* Angew. Chem. Int. Ed. 2011, 50, 3013-3016.

" Synthesis of ent-Nanolobatolide."
Cheng H.-M., Tian W., Peixoto P. A., Dhudshia B., and Chen D. Y. -K.* Angew. Chem. Int. Ed. 2011, 50, 4165-4168.

" Synthesis of Advanced Maoecrystal V Core Structure."
Dong L., Deng L., Lim Y.-H., Leung G. Y. C., and Chen D. Y. -K.* Chem. Eur. J. 2011, 17, 5778-5781.

" Chemical Synthesis and Biological Evaluation of the Englerin Analogues."
Chan K. P. and Chen D. Y. -K.* ChemMedChem. 2011, 6, 420-423.

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